Genetic mutations can significantly impact the methylation process, leading to various health issues. For instance, mutations in the MTHFR gene, such as C677T and A1298C, impair the body’s ability to convert folate into its active form, 5-MTHF, essential for methylation. This impairment can result in elevated homocysteine levels, increasing the risk of cardiovascular diseases, neurological disorders, disruption of hormone balance and complications during pregnancy .
Therefore, understanding and addressing genetic mutations affecting methylation is crucial for cellular repair, maintaining optimal health and preventing disease.
